Caspase-3 (176-277,)

CAT#: AR51471PU-N

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Recombinant human CASP3 protein, fused to His-tag at N-terminus, was expressed in E.coli.


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USD 1,070.00


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2 Weeks

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    • 250 ug


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Product Data
Description Recombinant human CASP3 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Species Human
Expression Host E. coli
Predicted MW 12 kDa
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity > 80 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_001341706
Locus ID 836
Cytogenetics 4q35.1
Synonyms CPP32; CPP32B; SCA-1
Summary The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protease
Protein Pathways Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis

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68 Mouse Clones