GAD1 / GAD67 (1-224, His-tag)

CAT#: AR51462PU-S

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Recombinant human GAD1 protein, fused to His-tag at N-terminus, was expressed in E.coli .

Product Datasheet for 'AR51462PU-S'

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USD 415.00

2 Weeks

    • 50 ug

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Product Data
Description Recombinant human GAD1 protein, fused to His-tag at N-terminus, was expressed in E.coli .
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 27.7 kDa
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity > 85 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
Preparation Liquid purified protein
Reference Data
RefSeq NP_000808
Locus ID 2571
Cytogenetics 2q31.1
Synonyms CPSQ1; GAD; SCP
Summary This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus


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68 Mouse Clones