MMP-2 (110-660, His-tag)

USD 400.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 64.7 kDa
Concentration 0.25 mg/ml (determined by Bradford assay)
Purity > 95 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_001121363
Locus ID 4313
Cytogenetics 16q12.2
Synonyms CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1
Summary This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Protein Families Druggable Genome, Protease
Protein Pathways Bladder cancer, GnRH signaling pathway, Leukocyte transendothelial migration, Pathways in cancer

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68 Mouse Clones