Complement factor B (His-tag)

CAT#: AR51361PU-S

Recombinant human CFB protein, fused to His-tag at N-terminus, was expressed in E.coli.


 Product Datasheet for 'AR51361PU-S'

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USD 320.00


Availability*
2 Weeks

Size
    • 0.1 mg


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Specifications

Product Data
Description Recombinant human CFB protein, fused to His-tag at N-terminus, was expressed in E.coli.
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGSSHHHHHH SSGLVPRGSQ SHMTPWSLAR PQGSCSLEGV EIKGGSFRLL QEGQALEYVC PSGFYPYPVQ TRTCRSTGSW STLKTQDQKT VRKAECRAIH CPRPHDFENG EYWPRSPYYN VSDEISFHCY DGYTLRGSAN RTCQVNGRWS GQTAICDNGA GYCSNPGIPI GTRKVGSQYR LEDSVTYHCS RGLTLRGSQR RTCQEGGSWS GTEPSCQDSF MYDTPQEVAE AFLSSLTETI EGVDAEDGHG PGEQQKR
Tag His-tag
Predicted MW 28.4 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity > 85 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
Preparation Liquid purified protein
Reference Data
RefSeq NP_001701
Locus ID 629
Cytogenetics 6p21.33
Synonyms AHUS4; ARMD14; BF; BFD; CFAB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2
Summary This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades

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