RAMP1 (27-117, His-tag)

CAT#: AR51338PU-S

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Recombinant human RAMP1 protein, fused to His-tag at N-terminus, was expressed in E.coli.


 Product Datasheet for 'AR51338PU-S'

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USD 400.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Description Recombinant human RAMP1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGSSHHHHHH SSGLVPRGSH MGSCQEANYG ALLRELCLTQ FQVDMEAVGE TLWCDWGRTI RSYRELADCT WHMAEKLGCF WPNAEVDRFF LAVHGRYFRS CPISGRAVRD PPGS
Tag His-tag
Predicted MW 12.9 kDa
Concentration 0.25 mg/ml (determined by Bradford assay)
Purity > 80 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_001295282
Locus ID 10267
Cytogenetics 2q37.3
Summary The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Vascular smooth muscle contraction

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