CD59 (26-102, His-tag) Human Protein

CAT#: AR51082PU-N

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CD59 (26-102, His-tag) human protein, 0.1 mg


Product Datasheet for 'AR51082PU-N'


USD 845.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description CD59 (26-102, His-tag) human protein, 0.1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGSSHHHHHH SSGLVPRGSH MGSLQCYNCP NPTADCKTAV NCSSDFDACL ITKAGLQVYN KCWKFEHCNF NDVTTRLREN ELTYYCCKKD LCNFNEQLEN
Tag His-tag
Predicted MW 11.3 kDa
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity >85% by SDS - PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Preparation Liquid purified protein
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000602
Locus ID 966
Cytogenetics 11p13
Synonyms 1F5; 16.3A5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20
Summary This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Complement and coagulation cascades, Hematopoietic cell lineage

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