Dickkopf-1 (32-266, His-tag)

CAT#: AR50894PU-N

Recombinant human DKK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.


 Product Datasheet for 'AR50894PU-N'

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USD 820.00


Availability*
2 Weeks

Size
    • 0.5 mg


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Specifications

Product Data
Description Recombinant human DKK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGSSHHHHHH SSGLVPRGSH MGSTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRH
Tag His-tag
Predicted MW 28.2 kDa
Concentration 1 mg/ml (determined by Bradford assay)
Purity > 90 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_036374
Locus ID 22943
Cytogenetics 10q21.1
Synonyms DKK-1; SK
Summary This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway
Protein Pathways Wnt signaling pathway

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