Complement factor D (26-253, His-tag)

CAT#: AR50701PU-N

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Recombinant human CFD protein, fused to His-tag at N-terminus, was expressed in E.coli.


 Product Datasheet for 'AR50701PU-N'

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USD 845.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Description Recombinant human CFD protein, fused to His-tag at N-terminus, was expressed in E.coli.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 26.6 kDa
Concentration 1 mg/ml (determined by Bradford assay)
Purity > 85 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
Preparation Liquid purified protein
Reference Data
RefSeq NP_001304264
Locus ID 1675
Cytogenetics 19p13.3
Synonyms ADIPSIN; ADN; DF; PFD
Summary This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades

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68 Mouse Clones