HMG-CoA lyase / HMGCL (28-325, His-tag) Human Protein

CAT#: AR50170PU-S

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HMG-CoA lyase / HMGCL (28-325, His-tag) human recombinant protein, 0.1 mg


Product Datasheet for 'AR50170PU-S'


USD 330.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description HMG-CoA lyase / HMGCL (28-325, His-tag) human recombinant protein, 0.1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGSSHHHHHH SSGLVPRGSH MGSHMTLPKR VKIVEVGPRD GLQNEKNIVS TPVKIKLIDM LSEAGLSVIE TTSFVSPKWV PQMGDHTEVL KGIQKFPGIN YPVLTPNLKG FEAAVAAGAK EVVIFGAASE LFTKKNINCS IEESFQRFDA ILKAAQSANI SVRGYVSCAL GCPYEGKISP AKVAEVTKKF YSMGCYEISL GDTIGVGTPG IMKDMLSAVM QEVPLAALAV HCHDTYGQAL ANTLMALQMG VSVVDSSVAG LGGCPYAQGA SGNLATEDLV YMLEGLGIHT GVNLQKLLEA GNFICQALNR KTSSKVAQAT CKL
Tag His-tag
Predicted MW 34.2 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity >85% by SDS - PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: 20 mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.4M Urea
Preparation Liquid purified protein
Protein Description Recombinant human HMGCL protein, fused to His-tag at N-terminus, was expressed in E.coli.
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000182
Locus ID 3155
Cytogenetics 1p36.11
Synonyms HL
Summary The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Protein Families Druggable Genome
Protein Pathways Butanoate metabolism, Metabolic pathways, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation

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