Glutathione peroxidase 2 / GPX2 (1-190, His-tag) Human Protein

CAT#: AR50150PU-N

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Glutathione peroxidase 2 / GPX2 (1-190, His-tag) human recombinant protein, 50 µg


Product Datasheet for 'AR50150PU-N'


USD 845.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Description Glutathione peroxidase 2 / GPX2 (1-190, His-tag) human recombinant protein, 50 µg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGSSHHHHHH SSGLVPRGSH MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLC GTTTRDFTQL NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI
Tag His-tag
Predicted MW 24.1 kDa
Concentration 0.25 mg/ml (determined by Bradford assay)
Purity >95% by SDS - PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: 20 mM Tris-HCl buffer (pH7.5) containing 40% glycerol, 0.15M NaCl, 1mM DTT
Preparation Liquid purified protein
Protein Description Recombinant human GPX2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_002074
Locus ID 2877
Cytogenetics 14q23.3
Synonyms GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI; GSHPx-2; GSHPX-GI
Summary The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Protein Families Druggable Genome
Protein Pathways Arachidonic acid metabolism, Glutathione metabolism

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