CD254 / RANKL (140-317, His-tag)

CAT#: AR39033PU-L

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Recombinant human RANKL protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.


 Product Datasheet for 'AR39033PU-L'

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USD 820.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Description Recombinant human RANKL protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 22.3 kDa
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity > 80 %
Buffer 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Preparation Liquid purified protein
Reference Data
RefSeq NP_003692
Locus ID 8600
Cytogenetics 13q14.11
Synonyms CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
Summary This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction

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68 Mouse Clones