CD80 (Fc portion) Human Protein

CAT#: AR31192PU-S

CD80 (Fc portion) human recombinant protein, 20 µg

Specifications

Product Data

• Species: Human
• Expression Host: CHO
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  VIHVTKEVKE VATLSCGHNV SVEELAQTRI YWQKEKKMVL TMMSGDMNIW PEYKNRTIFD ITNNLSIVIL ALRPSDEGTY ECVVLKYEKD AFKREHLAEV TLSVKADFPT PSISDFEIPT SNIRRIICST SGGFPEPHLS WLENGEELNA INTTVSQDPE TELYAVSSKL DFNMTTNHSF MCLIKYGHLR VNQTFNWNTT KQEHFPDNGG PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG K
• Predicted MW: 50.0 kDa
• Purity: >95% pure by SDS-PAGE and HPLC analyses
• Presentation: Purified
• Buffer: Lyophilized from 10 mM Sodium Phosphate, pH 7.5
• Bioactivity: Biological: Determined by its ability to inhibit alkalinephosphatase activity in differentiating MC3T3/E1 cells. The expected ED₅₀ for this effect is 0.5-1.5 μg/ml.
• Endotoxin: < 0.1 ng per µg (1EU/µg)
• Reconstitution: Restore in Water to a concentration of 0.1-1.0 mg/ml.
  This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use.
• Preparation: Lyophilized purified protein
• Protein Description: Recombinant Human B7-1Fc is a homodimeric B7-1 fusion protein, whose monomer contains a total of 441 amino acid residues, consisting of 211 amino acid residues corresponding to the extracellular domain of human B7-1, fused to the Fc portion of human IgG1.
  The calculated molecular weight of the B7-1 Fc monomer is 50.0 kDa.
• Note: Centrifuge the vial prior to opening!
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_005182
• Locus ID: 941
• UniProt ID: P33681, A0N0P2
• Cytogenetics: 3q13.33
• Synonyms: B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7
• Summary: The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
• Protein Families: Druggable Genome, Transcription Factors, Transmembrane
• Protein Pathways: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis