Somatotropin / Growth Hormone / GH1 Human Protein

CAT#: AR31189PU-S

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Somatotropin / Growth Hormone / GH1 human recombinant protein, 10 µg


Product Datasheet for 'AR31189PU-S'


USD 145.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Somatotropin / Growth Hormone / GH1 human recombinant protein, 10 µg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MFPTIPLSRL FDNAMLRAHR LHQLAFDTYQ EFEEAYIPKE QKYSFLQNPQ TSLCFSESIP TPSNREETQQ KSNLELLRIS LLLIQSWLEP VQFLRSVFAN SLVYGASDSN VYDLLKDLEE GIQTLMGRLE DGSPRTGQIF KQTYSKFDTN SHNDDALLKN YGLLYCFRKD MDKVETFLRI VQCRSVEGSC GF
Predicted MW 22.3 kDa
Purity >98% pure by SDS-PAGE gel and HPLC analyses
Buffer Presentation State: Purified
State: Lyophilized (0.2μ Sterile filtered) purified protein
Bioactivity Biological: Determined by its ability to stimulate the proliferation of rat Nb2-11 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Reconstitution Restore in water to a concentration of 0.1-1.0 mg/ml. 
Do not vortex.  For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Preparation Lyophilized (0.2μ Sterile filtered) purified protein
Protein Description Recombinant Human Growth Hormone is a 22.3 kDa, single, non-glycosylated polypeptide chain containing 192 amino acid residues.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000506
Locus ID 2688
Cytogenetics 17q23.3
Synonyms GH; GH-N; GHB5; GHN; hGH-N; IGHD1A; IGHD1B; IGHD2
Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction

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