BMP2 / BMP2A (CHO cell derived)

CAT#: AR31188PU-S

Recombinant Human BMP-2 derived from CHO cells is a homodimeric glycoprotein that consists of two 114 amino acid polypeptide chains linked by a single disulfide bond. Due to glycosylation, CHO cell-derived Human BMP-2 migrates at an apparent molecular weight of approximately 28-29 kDa by SDS-PAGE analysis under non-reducing conditions.
Mature sequence is complete identical with Mouse and Rat.


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USD 140.00


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2 Weeks

Size
    • 2 ug


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Product Data
Description Recombinant Human BMP-2 derived from CHO cells is a homodimeric glycoprotein that consists of two 114 amino acid polypeptide chains linked by a single disulfide bond. Due to glycosylation, CHO cell-derived Human BMP-2 migrates at an apparent molecular weight of approximately 28-29 kDa by SDS-PAGE analysis under non-reducing conditions.
Mature sequence is complete identical with Mouse and Rat.
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence QAKHKQRKRL KSSCKRHPLY VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV NSKIPKACCV PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR
Tag Tag Free
Predicted MW 26.0 kDa
Purity > 95 % pure by SDS-PAGE gel and HPLC analyses.
Bioactivity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 40-100 ng/ml.
Endotoxin < 0.1 ng/µg (1EU/µg)
Reconstitution Restore in water to a concentration of 0.1-1.0 mg/ml.
This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use.
Preparation Lyophilized (sterile filtered) purified protein
Reference Data
RefSeq NP_001191
Locus ID 650
Cytogenetics 20p12.3
Synonyms BDA2; BMP2A
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Stem cell relevant signaling - TGFb/BMP signaling pathway, Secreted Protein, ES Cell Differentiation/IPS, Transmembrane, Adult stem cells, Cancer stem cells, Embryonic stem cells, Induced pluripotent stem cells, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway, Pathways in cancer, Basal cell carcinoma

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