Interleukin-24 / IL24 (His-tag) Human Protein

CAT#: AR31174PU-N

Interleukin-24 / IL24 (His-tag) human recombinant protein, 20 µg

Specifications

Product Data

• Species: Human
• Expression Host: CHO
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  QEFHFGPCQV KGVVPQKLWE AFWAVKDTMQ AQDNITSARL LQQEVL QNVS DAESCYLVHT LLEFYLKTVF KNYHNRTVEV RTLKSFSTLA N NFVLIVSQL QPSQENEMFS IRDSAHRRFL LFRRAFKQLD VEAALTK ALG EVDILLTWMQ KFYKLHHHHHH
• Tag: His-tag
• Predicted MW: 18.9 kDa
• Purity: >95% by SDS-PAGE and HPLC
• Presentation: Purified
• Buffer: Presentation State: Purified
  State: Lyophilized purified protein
  Stabilizer: None
• Endotoxin: < 0.1 ng per µg of IL-24
• Reconstitution: Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex
• Preparation: Lyophilized purified protein
• Protein Description: Recombinant Human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_001172085
• Locus ID: 11009
• UniProt ID: Q13007
• Cytogenetics: 1q32.1
• Synonyms: C49A; FISP; IL10B; MDA7; MOB5; ST16
• Summary: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway