BMP7

CAT#: AR31155PU-N

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Recombinant Human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor.


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USD 330.00


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2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Recombinant Human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor.
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence MANVAENSSS DQRQACKKHE LYVSFRDLGW QDWIIAPEGY AAYYCE GECA FPLNSYMNAT NHAIVQTLVH FINPETVPKP CCAPTQLNAI S VLYFDDSSN VILKKYRNMV VRACGCH
Tag Tag Free
Predicted MW 28.8 kDa
Purity > 98 % by SDS-PAGE & HPLC analysis
Buffer PBS without stabilizers
Bioactivity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 µg/ml.
Endotoxin < 0.1 ng per µg of BMP-7
Reconstitution Restore in PBS to a concentration not lower than 50 µg/ml.
The lyophilized sTIE-2/hFc is soluble in water and most aqueous buffers.
Preparation Lyophilized purified protein
Reference Data
RefSeq NP_001710
Locus ID 655
Cytogenetics 20q13.31
Synonyms OP-1
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway
Protein Pathways Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway

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BOGO Free lysates
68 Mouse Clones