Dickkopf-2 (DKK2) Human Protein

CAT#: AR31144PU-S

Dickkopf-2 (DKK2) human recombinant protein, 2 µg

Size: 2 ug 10 ug


USD 164.00

2 Weeks*

Size
    • 2 ug

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Specifications

Product Data
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence
SQIGSSRAKL NSIKSSLGGE TPGQAANRSA GMYQGLAFGG SKKGKNLGQA YPCSSDKECE VGRYCHSPHQ GSSACMVCRR KKKRCHRDGM CCPSTRCNNG ICIPVTESIL TPHIPALDGT RHRDRNHGHY SNHDLGWQNL GRPHTKMSHI KGHEGDPCLR SSDCIEGFCC ARHFWTKICK PVLHQGEVCT KQRKKGSHGL EIFQRCDCAK GLSCKVWKDA TYSSKARLHV CQKI
Predicted MW 25.8 kDa
Purity >98% pure by SDS-PAGE and HPLC analyses
Presentation Purified
Buffer Presentation State: Purified
State: Lyophilized (0.2μ Sterile filtered) purified protein from 10 mM Sodium Phosphate, pH 7.5 + 150 mM NaCl
Bioactivity Biological: Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3 E1 cells.  The expected ED50 for this effect is 0.5– 1.0 µg/ml.
Reconstitution Restore in water to 0.1-1.0 mg/ml
Preparation Lyophilized (0.2μ Sterile filtered) purified protein from 10mM Sodium Phosphate, pH 7.5 + 150mM NaCl.
Protein Description Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues.
Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_055236
Locus ID 27123
UniProt ID Q9UBU2
Cytogenetics 4q25
Synonyms DKK-2
Summary This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway
Protein Pathways Wnt signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.