Apolipoprotein A I / APO AI
Purified Human Apo A1 prepared by Ultracentrifugation, Delipidation and Gel Filtration.
Product Datasheet for 'AR31065PU-N'
|Description||Purified Human Apo A1 prepared by Ultracentrifugation, Delipidation and Gel Filtration.|
|Predicted MW||28 kDa|
|Purity||> 90 %|
|Buffer||0.05 M Sodium Chloride, 0.01 M Sodium Carbonate without preservatives or stabilizers|
|Reconstitution||Restore with 1.0 ml distilled water.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. We recommend that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% Sodium Azide is recommended.
|Preparation||Lyophilized purified protein|
|Summary||This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]|
|Protein Families||Druggable Genome, Secreted Protein|
|Protein Pathways||PPAR signaling pathway|
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|PH310762||APOA1 MS Standard C13 and N15-labeled recombinant protein (NP_000030)||