SERPINE1 / PAI1 (Wild type) Mouse Protein

CAT#: AR31009PU-N

SERPINE1 / PAI1 (Wild type) mouse recombinant protein, 0.5 mg

Specifications

Product Data

• Species: Mouse
• Expression Host: E. coli
• Predicted MW: 43 kDa
• Concentration: lot specific
• Purity: >98% by SDS-PAGE.
  80 +/- 5% active by uPA titration. Purified by Column chromatography
• Presentation: Purified
• Buffer: Presentation State: Purified
  State: Liquid purified protein
  Buffer System: 0.05M Sodium Acetate, 0.1M Sodium Chloride, 1 mM EDTA, pH 5.0 without preservatives
• Preparation: Liquid purified protein
• Protein Description: Recombinant Human Plasminogen Activator Inhibitor 1 (PAI-1), wild type. Does not contain a fusion partner.
• Storage: Store (in aliquots) at -70°C
  Aliquot to avoid multiple freeze/thaw cycles.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_000593
• Locus ID: 5054
• UniProt ID: P05121, A0A024QYT5
• Cytogenetics: 7q22.1
• Synonyms: PAI; PAI-1; PAI1; PLANH1
• Summary: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades, p53 signaling pathway