Gremlin-1 / GREM1 Human Protein

CAT#: AR26007PU-N

Gremlin-1 / GREM1 human recombinant protein, 50 µg

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MKKKGSQGAI PPPDKAQHND SEQTQSPQQP GSRNRGRGQG RGTAMPGEEV LESSQEALHV TERKYLKRDW CKTQPLKQTI HEEGCNSRTI INRFCYGQCN SFYIPRHIRK EEGSFQSCSF CKPKKFTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
• Predicted MW: 18.4 kDa
• Purity: >95% by SDS-PAGE and Silver staining
• Presentation: Purified
• Buffer: Presentation State: Purified
  State: Lyophilized protein
  Buffer System: 50 mM Acetic Acid
  Stabilizer: None
• Endotoxin: < 0.1 ng per μg of Grem1
• Reconstitution: Human Grem1 should be reconstituted in 50mM Acetic Acid or sterile water to a concentration of 0.1 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
• Preparation: Lyophilized protein
• Protein Description: Recombinant Human Gremlin-1, aa. 161.
  Result by N-terminal sequencing: MKKKGSQGAI
• Note: Protein RefSeq: NP_001178252.1
  mRNA RefSeq: NM_013372
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_001178251
• Locus ID: 26585
• UniProt ID: B3KTR9
• Cytogenetics: 15q13.3
• Synonyms: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
• Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
• Protein Families: ES Cell Differentiation/IPS, Secreted Protein