RBM8A / RBM8 (1-174, His-tag) Human Protein

CAT#: AR09930PU-L

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RBM8A / RBM8 (1-174, His-tag) human recombinant protein, 0.25 mg


Product Datasheet for 'AR09930PU-L'


USD 1,105.00


Availability*
2 Weeks

Size
    • 250 ug


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Specifications

Product Data
Description RBM8A / RBM8 (1-174, His-tag) human recombinant protein, 0.25 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MADVLDLHEA GGEDFAMDED GDESIHKLKE KAKKRKGRGF GSEEGSRARM REDYDSVEQD GDEPGPQRSV EGWILFVTGV HEEATEEDIH DKFAEYGEIK NIHLNLDRRT GYLKGYTLVE YETYKEAQAA MEGLNGQDLM GQPISVDWCF VRGPPKGKRR GGRRRSRSPD RRRRLEHHHH HH
Tag His-tag
Predicted MW 20.9 kDa
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity >90%
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl, 1mM DTT
Preparation Liquid purified protein
Protein Description Recombinant human RBM8A protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_005096
Locus ID 9939
Cytogenetics 1q21.1
Synonyms BOV-1A; BOV-1B; BOV-1C; C1DELq21.1; DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1
Summary This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013]
Protein Families Druggable Genome
Protein Pathways Spliceosome

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