HIP2 / UBE2K (1-200, His-tag) Human Protein

CAT#: AR09834PU-N

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HIP2 / UBE2K (1-200, His-tag) human recombinant protein, 50 µg


Product Datasheet for 'AR09834PU-N'


USD 415.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Description HIP2 / UBE2K (1-200, His-tag) human recombinant protein, 50 µg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMANI AVQRIKREFK EVLKSEETSK NQIKVDLVDE NFTELRGEIA GPPDTPYEGG RYQLEIKIPE TYPFNPPKVR FITKIWHPNI SSVTGAICLD ILKDQWAAAM TLRTVLLSLQ ALLAAAEPDD PQDAVVANQY KQNPEMFKQT ARLWAHVYAG APVSSPEYTK KIENLCAMGF DRNAVIVALS SKSWDVETAT ELLLSN
Tag His-tag
Predicted MW 26.5 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity >95%
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: 20mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 10% glycerol, 50mM NaCl
Preparation Liquid purified protein
Protein Description Recombinant human UBE2K protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_001104582
Locus ID 3093
Cytogenetics 4p14
Synonyms E2-25K; HIP2; HYPG; LIG; UBC1
Summary The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Ubiquitin mediated proteolysis

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