Inositol monophosphatase / IMPA1 (1-277, His-tag)

CAT#: AR09675PU-L

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Recombinant human IMPA1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.


 Product Datasheet for 'AR09675PU-L'

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USD 820.00


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2 Weeks

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    • 500 ug


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Product Data
Description Recombinant human IMPA1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 32.3 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity > 95 %
Buffer 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_001138350
Locus ID 3612
Cytogenetics 8q21.13
Synonyms IMP; IMPA; MRT59
Summary This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Protein Families Druggable Genome
Protein Pathways Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

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68 Mouse Clones