Cyclin H (1-323, His-tag)

CAT#: AR09425PU-N

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Recombinant human Cyclin H, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.


 Product Datasheet for 'AR09425PU-N'

  View other "CCNH" proteins (5)

USD 290.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description Recombinant human Cyclin H, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 39.8 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity > 90 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM DTT, 30% glycerol, 2 mM EDTA, 0.1 M NaCl
Preparation Liquid purified protein
Reference Data
RefSeq NP_001186118
Locus ID 902
Cytogenetics 5q14.3
Synonyms CAK; CycH; p34; p37
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Cell cycle, Nucleotide excision repair

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68 Mouse Clones