HSD17B10 / ERAB (12-261, His-tag)

CAT#: AR09418PU-L

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Recombinant HSD17B10 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.


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USD 720.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Description Recombinant HSD17B10 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 28.1 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Buffer 20 mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1 mM DTT, and 100 mM NaCl
Preparation Liquid purified protein
Reference Data
RefSeq NP_001032900
Locus ID 3028
Cytogenetics Xp11.22
Synonyms 17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; HSD10MD; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD; SDR5C1
Summary This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Metabolic pathways, Valine, leucine and isoleucine degradation

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68 Mouse Clones