Superoxide dismutase 2 / SOD2 (25-222, His-tag)

CAT#: AR09412PU-L

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Recombinant human SOD2 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.


Product Datasheet for 'AR09412PU-L'


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USD 745.00


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2 Weeks

Size
    • 500 ug


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Product Data
Description Recombinant human SOD2 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 24.4 kDa
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity > 95 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Bioactivity Specific activity is > 1,000 units/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.5 at 25°C.
Preparation Liquid purified protein
Reference Data
RefSeq NP_000627
Locus ID 6648
Cytogenetics 6q25.3
Synonyms IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6
Summary This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Huntington's disease

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