SMAD4 (1-552, His-tag)

CAT#: AR09143PU-S

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Recombinant SMAD4 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.


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USD 250.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description Recombinant SMAD4 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 62.6 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity > 90 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_005350
Locus ID 4089
Cytogenetics 18q21.2
Synonyms DPC4; JIP; MADH4; MYHRS
Summary This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Adherens junction, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway, Wnt signaling pathway

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