COMT (51-271)

CAT#: AR09141PU-L

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Recombinant human COMT protein was expressed in E.coli and purified by using conventional chromatography techniques.


Product Datasheet for 'AR09141PU-L'


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USD 1,620.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Description Recombinant human COMT protein was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Expression Host E. coli
Predicted MW 24.4 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity > 95 % by SDS-PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM MgCl2, 10% glycerol
Endotoxin < 1.0 EU per 1 µg of protein (determined by LAL method)
Preparation Liquid purified protein
Reference Data
RefSeq NP_000745
Locus ID 1312
Cytogenetics 22q11.21
Synonyms HEL-S-98n
Summary Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Metabolic pathways, Tyrosine metabolism

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68 Mouse Clones