BMP2 / BMP2A (283-396)

CAT#: AR09127PU-L

Recombinant human BMP-2 protein was expressed in E.coli and purified by using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.


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2 Weeks

Size
    • 0.5 mg


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Specifications

Product Data
Description Recombinant human BMP-2 protein was expressed in E.coli and purified by using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.
Species Human
Expression Host E.Coli
Expression cDNA Clone or AA Sequence MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Tag Tag Free
Predicted MW kDa
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity > 95 % by SDS - PAGE
Buffer 10 mM Sodium Citrate (pH 3.5) containing 10% glycerol
Endotoxin < 1.0 EU per 1 µg of protein (determined by LAL method)
Preparation Liquid purified protein
Reference Data
RefSeq NP_001191
Locus ID 650
Cytogenetics 20p12.3
Synonyms BDA2; BMP2A
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Stem cell relevant signaling - TGFb/BMP signaling pathway, Secreted Protein, ES Cell Differentiation/IPS, Transmembrane, Adult stem cells, Cancer stem cells, Embryonic stem cells, Induced pluripotent stem cells, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway, Pathways in cancer, Basal cell carcinoma

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