Insulin-like growth factor I / IGF1 Human Protein

CAT#: AR09044PU-L

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Recombinant Human IGF-1 was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.


Product Datasheet for 'AR09044PU-L'


USD 330.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Description Recombinant Human IGF-1 was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGPETLCGAE LVDALQFVCG DRGFYFNKPT GYGSSSRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPAKS A
Predicted MW 7.7 kDa
Concentration 1 mg/ml (determined by Bradford assay)
Purity > 95 % pure by SDS-PAGE
Buffer PBS, pH 7.4
Bioactivity Measured in a cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 range ≤ 5 ng/ml.
Preparation Liquid purified protein
Reference Data
RefSeq NP_000609
Locus ID 3479
Cytogenetics 12q23.2
Synonyms IGF; IGF-I; IGFI; MGF
Summary The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Dilated cardiomyopathy, Focal adhesion, Glioma, Hypertrophic cardiomyopathy (HCM), Long-term depression, Melanoma, mTOR signaling pathway, Oocyte meiosis, p53 signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

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