Cofilin-1 (1-166, His-tag)

CAT#: AR09012PU-L

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Recombinant human Cofilin, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.


 Product Datasheet for 'AR09012PU-L'

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USD 1,070.00


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2 Weeks

Size
    • 500 ug


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Product Data
Description Recombinant human Cofilin, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 20 kDa
Concentration 1.0 mg/ml
Purity > 95 % >/= 95% by SDS PAGE
Buffer 20 mM Tris pH 8.0, 10 % Glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_005498
Locus ID 1072
Cytogenetics 11q13.1
Synonyms CFL; cofilin; HEL-S-15
Summary The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. [supplied by OMIM, Apr 2004]
Protein Families Druggable Genome
Protein Pathways Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton

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68 Mouse Clones