Thyroglobulin

CAT#: AR05089PU-N

Native Thyroglobulin from bovine thyroid glands is a precursor of the iodated thyroid hormones thyroxine (T4) and triiodothyronine (T3) that affect protein, fat and carbohydrate metabolism. Thyroglobulin is produced by thyrocytes within the thyroid gland and is stored within the follicular lumen.


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5 Days

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    • 0.1 g


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Product Data
Description Native Thyroglobulin from bovine thyroid glands is a precursor of the iodated thyroid hormones thyroxine (T4) and triiodothyronine (T3) that affect protein, fat and carbohydrate metabolism. Thyroglobulin is produced by thyrocytes within the thyroid gland and is stored within the follicular lumen.
Species Human
Expression Host Other
Tag Tag Free
Concentration 5.0 mg/ml
Preparation Liquid purified protein
Reference Data
RefSeq NP_003226
Locus ID 7038
Cytogenetics 8q24.22
Synonyms AITD3; TGN
Summary Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Protein Families Druggable Genome
Protein Pathways Autoimmune thyroid disease

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