PCNA (1-261)

CAT#: AR03008PU-L

Recombinant Human PCNA, was expressed in E.coli and purified by conventional chromatography techniques.


 Product Datasheet for 'AR03008PU-L'

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USD 820.00


Availability*
2 Weeks

Size
    • 0.5 mg


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Specifications

Product Data
Description Recombinant Human PCNA, was expressed in E.coli and purified by conventional chromatography techniques.
Species Human
Expression Host E.Coli
Expression cDNA Clone or AA Sequence MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK IADMGHLKYY LAPKIEDEEG S
Tag Tag Free
Predicted MW 28 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity > 95 % by SDS PAGE
Buffer 20mM Tris-HCl, pH 7.5 containing 2mM EDTA and 20% Glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_002583
Locus ID 5111
Cytogenetics 20p12.3
Synonyms ATLD2; ATLD2
Summary The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Protein Families Stem cell - Pluripotency, Druggable Genome
Protein Pathways DNA replication, Base excision repair, Nucleotide excision repair, Mismatch repair, Cell cycle

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