Cardiac Troponin T Human Protein
|Description||Cardiac Troponin T human protein, 50 µg|
|Protein Source||Cardiac muscle|
|Purity||>98% pure by SDS-PAGE|
|Buffer||Presentation State: Purified
State: Liquid purified protein
Buffer System: Urea/Tris buffer, pH 7.5 (7 M Urea, 5 mM EDTA, 15 mM Mercaptoethanol, 20 mM Tris)
|Preparation||Liquid purified protein|
|Protein Description||Purified Human cardiac Troponin T, also known as cTnT. Immunological identity has been confirmed by reaction with a monoclonal antibody specific for Troponin T cardiac isoform.|
|Note||Caution: The blood of the tissue donor for this product was tested and found negative for antibodies to HBsAg, and HIV- and HIV-2 antibodies and HVC. Nevertheless, all products from human sources should be handled as potentially infectious.|
|Storage||Store the product undiluted at -20°C.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Synonyms||CMD1D; CMH2; CMPD2; cTnT; LVNC6; RCM3; TnTC|
|Summary||The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]|
|Protein Families||Druggable Genome|
|Protein Pathways||Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)|
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