Thyroxine-binding globulin /TBG Human Protein

CAT#: AR05090PU-N

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Thyroxine-binding globulin /TBG human protein, 1 mg



USD 613.00


Availability*
5 Days

Size
    • 1 mg


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Specifications

Product Data
Species Human
Protein Source Serum
Predicted MW 55 kDa
Concentration N/A
Purity >98% pure by SDS-PAGE
Buffer Presentation State: Purified
State: Lyophilized purified protein from Human Serum
Buffer System: Ammonium Bicarbonate
Preservative: None
Stabilizer: None
Reconstitution Restore with sterile PBS containing 0.15M NaCl. 
For long term storage up to 12 months the addition of 0.09% Sodium Azide is recommended.
N.B. For Functional Studies do not Add Sodium Azide. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. We recommend that the vial is gently mixed after reconstitution.
Preparation Lyophilized purified protein from Human Serum
Applications ELISA.
Protein Description Thyroxine Binding Globulin (TBG) is a serpin produced in the liver with high affinity for the thyroid hormones T3 and T4. TBG reversibly binds T3 and T4, enabling their circulation around the bloodstream.
Note Caution: A full Health and Safety assessment is available upon request) Starting material donor tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, Hepatitis C antibody, Syphilis and HIV antigen.
Storage After reconstitution store undiluted at -20°C.
Avoid repeated freezing and thawing as this may denature the protein.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000345
Locus ID 6906
Cytogenetics Xq22.3
Synonyms TBG; TBGQTL
Summary There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
Protein Families Druggable Genome, Secreted Protein
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