GAD65 (GAD2) (NM_001134366) Human Mass Spec Standard

CAT#: PH325984

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GAD2 MS Standard C13 and N15-labeled recombinant protein (NP_001127838)



  View other "GAD2" proteins (7)

USD 2,260.00


Availability*
3 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description GAD2 MS Standard C13 and N15-labeled recombinant protein (NP_001127838)
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC225984
Predicted MW 65.4 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80°C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_001127838
RefSeq Size 2419
RefSeq ORF 1755
Synonyms GAD65
Locus ID 2572
UniProt ID Q05329, Q5VZ30
Cytogenetics 10p12.1
Summary This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Protein Families Druggable Genome
Protein Pathways Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus

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Other Versions

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