MET (NM_000245) Human Mass Spec Standard

CAT#: PH317003

MET MS Standard C13 and N15-labeled recombinant protein (NP_000236)


  View other "MET" proteins (9)

USD 3,255.00

3 Weeks*

Size
    • 10 ug

Product Images

Frequently bought together (2)
MET mouse monoclonal antibody, clone OTI1E6 (formerly 1E6)
    • 100 ul

USD 447.00


Transient overexpression lysate of met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 1
    • 100 ug

USD 665.00

Specifications

Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC217003
Predicted MW 155.54 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_000236
RefSeq Size 6641
RefSeq ORF 4170
Synonyms AUTS9; c-Met; DFNB97; HGFR; RCCP2
Locus ID 4233
UniProt ID P08581, A0A024R759
Cytogenetics 7q31.2
Summary This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.