PADI1(PADI1) (NM_013358) Human Mass Spec Standard

CAT#: PH313501

PADI1 MS Standard C13 and N15-labeled recombinant protein (NP_037490)

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USD 1,995.00

3 Weeks

    • 10 ug

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Product Data
Description PADI1 MS Standard C13 and N15-labeled recombinant protein (NP_037490)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213501
Predicted MW 74.5 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_037490
RefSeq Size 2711
RefSeq ORF 1989
Synonyms HPAD10; PAD1; PDI; PDI1
Locus ID 29943
Cytogenetics 1p36.13
Summary This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008].
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