Factor VII(F7) (NM_019616) Human Mass Spec Standard

CAT#: PH313143

F7 MS Standard C13 and N15-labeled recombinant protein (NP_062562)

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USD 1,995


Availability*
3 Weeks

Size
    • 10 ug

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Specifications

Product Data
Description F7 MS Standard C13 and N15-labeled recombinant protein (NP_062562)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213143
Predicted MW 28 kDa
Protein Sequence
Tag C-MYC/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_062562
RefSeq Size 2412
RefSeq ORF 1341
Synonyms SPCA; SPCA
Locus ID 2155
Cytogenetics 13q34
Summary This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015].
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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