Factor XI(F11) (NM_000128) Human Mass Spec Standard

CAT#: PH313056

F11 MS Standard C13 and N15-labeled recombinant protein (NP_000119)

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USD 1,995.00

3 Weeks

    • 10 ug

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Product Data
Description F11 MS Standard C13 and N15-labeled recombinant protein (NP_000119)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213056
Predicted MW 69.9 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_000119
RefSeq Size 2217
RefSeq ORF 1875
Synonyms FXI; FXI
Locus ID 2160
Cytogenetics 4q35.2
Summary This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008].
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.