Dopamine beta Hydroxylase (DBH) (NM_000787) Human Mass Spec Standard

CAT#: PH312355

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DBH MS Standard C13 and N15-labeled recombinant protein (NP_000778)



  View other "DBH" proteins (3)

USD 2,260.00


Availability*
3 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description DBH MS Standard C13 and N15-labeled recombinant protein (NP_000778)
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC212355
Predicted MW 69.06 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80°C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_000778
RefSeq Size 2812
RefSeq ORF 1851
Synonyms DBM; ORTHYP1
Locus ID 1621
Cytogenetics 9q34.2
Summary The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Metabolic pathways, Tyrosine metabolism

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Other Versions

Frequently bought together (2)
Transient overexpression lysate of dopamine beta-hydroxylase (dopamine beta-monooxygenase) (DBH)
    • 100 ug

USD 550.00


Rabbit polyclonal antibody to Dopamine beta-Hydroxylase (dopamine beta-hydroxylase (dopamine beta-monooxygenase))
    • 100 ul

USD 430.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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