SOCS3 (NM_003955) Human Mass Spec Standard

CAT#: PH309305

SOCS3 MS Standard C13 and N15-labeled recombinant protein (NP_003946)


  View other "SOCS3" proteins (1)

USD 3,255.00

3 Weeks*

Size
    • 10 ug

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Frequently bought together (1)
SOCS3 mouse monoclonal antibody, clone OTI3D3 (formerly 3D3)
    • 100 ul

USD 447.00

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Specifications

Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC209305
Predicted MW 24.8 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_003946
RefSeq Size 2737
RefSeq ORF 675
Synonyms ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3
Locus ID 9021
UniProt ID O14543, Q6FI39
Cytogenetics 17q25.3
Summary This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

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