Prothrombin(F2) (NM_000506) Human Mass Spec Standard

CAT#: PH308589

F2 MS Standard C13 and N15-labeled recombinant protein (NP_000497)

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USD 1,995.00

3 Weeks

    • 10 ug

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Product Data
Description F2 MS Standard C13 and N15-labeled recombinant protein (NP_000497)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC208589
Predicted MW 70.01 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_000497
RefSeq Size 1997
RefSeq ORF 1866
Synonyms PT; RPRGL2; THPH1
Locus ID 2147
Cytogenetics 11p11.2
Summary Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
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