alpha 2 Macroglobulin(A2M) (NM_000014) Human Mass Spec Standard

CAT#: PH307905

A2M MS Standard C13 and N15-labeled recombinant protein (NP_000005)

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USD 1,995

3 Weeks

    • 10 ug

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Product Data
Description A2M MS Standard C13 and N15-labeled recombinant protein (NP_000005)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC207905
Predicted MW 163.28 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_000005
RefSeq Size 4678
RefSeq ORF 4422
Synonyms A2MD; CPAMD5; FWP007; S863-7
Locus ID 2
Cytogenetics 12p13.31
Summary Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. [UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.