SIRP alpha (SIRPA) (NM_080792) Human Mass Spec Standard
CAT#: PH307315
SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_542970)
Specifications
Product Data | |
Tag | C-Myc/DDK |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | RC207315 |
Predicted MW | 54.8 kDa |
Protein Sequence |
>RC207315 protein sequence
Red=Cloning site Green=Tags(s) MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVSVAAGESAILHCTVTSLIPVGPIQWFR GAGPARELIYNQKEGHFPRVTTVSESTKRENMDFSISISNITPADAGTYYCVKFRKGSPDTEFKSGAGTE LSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHS TAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQ RLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSA HPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALYLVRIRQKKAQGSTSSTRLHEPEKNAREIT QDTNDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEP SFSEYASVQVPRK TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_542970 |
RefSeq Size | 3868 |
RefSeq ORF | 1509 |
Synonyms | BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP |
Locus ID | 140885 |
UniProt ID | P78324 |
Cytogenetics | 20p13 |
Summary | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome, Phosphatase, Transmembrane |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC409074 | SIRPA HEK293T cell transient overexpression lysate (as WB positive control) |
USD 134.00 |
|
LC421878 | SIRPA HEK293T cell transient overexpression lysate (as WB positive control) |
USD 206.00 |
|
LC421879 | SIRPA HEK293T cell transient overexpression lysate (as WB positive control) |
USD 206.00 |
|
LY409074 | Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 3 |
USD 436.00 |
|
LY421878 | Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 1 |
USD 665.00 |
|
LY421879 | Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 2 |
USD 665.00 |
|
PH316320 | SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_001035112) |
USD 3,255.00 |
|
PH322380 | SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_001035111) |
USD 3,255.00 |
|
TP307315 | Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 3, 20 µg |
USD 867.00 |
|
TP316320 | Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 2, 20 µg |
USD 867.00 |
|
TP322380 | Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 1, 20 µg |
USD 867.00 |
|
TP723932 | Human SIRP alpha Protein, hFc-His Tag |
USD 575.00 |
|
TP762372 | Purified recombinant protein of Human signal-regulatory protein alpha (SIRPA), transcript variant 1, Glu31-Ile373, with N-terminal His tag, expressed in E.coli, 50ug |
USD 249.00 |
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