emopamil binding protein(EBP) (NM_006579) Human Mass Spec Standard

CAT#: PH301706

EBP MS Standard C13 and N15-labeled recombinant protein (NP_006570)

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USD 1,995.00


Availability*
3 Weeks

Size
    • 10 ug

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Specifications

Product Data
Description EBP MS Standard C13 and N15-labeled recombinant protein (NP_006570)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC201706
Predicted MW 26.2 kDa
Protein Sequence
Tag C-MYC/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_006570
RefSeq Size 1073
RefSeq ORF 690
Synonyms CDPX2; CHO2; CPX; CPXD
Locus ID 10682
Cytogenetics Xp11.23
Summary The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]
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