Stable Cell Line

CAT#: SL500073

Human Doublecortin-like Kinase 1 DCAMKL1 Stable Cell Line - NIH3T3

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USD 12,888


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Product Data
Description Human Doublecortin-like Kinase 1 DCAMKL1 Stable Cell Line - NIH3T3
Gene DCLK1
Accn NM_004734
Synonyms CL1; CLICK1; DCAMKL1; DCDC3A; DCLK
Host Cell NIH3T3
Format Cryopreserved cells, 2 x 10E6 cells/vial
Mycoplasma Negative by MycoAlert Kit, Lonza
Cell Line Validation Western blot
Background Doublecortin-like Kinase 1 (DCAMKL1) is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, a C-terminal serine/threonine protein kinase domain and a serine/proline-rich domain which is between the doublecortin and the protein kinase domains. Different domains reveal alterative functions. N-terminal domains bind microtubules and regulate microtubule polymerization. The C-terminal domain shows substantial homology to Ca2+/calmodulin-dependent protein kinase. However, the serine/proline-rich domain functions in mediating multiple protein-protein interactions. DCAMKL1 involves in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. DCAMKL1 expression is up-regulated by brain-derived neurotrophic factor and is associated with memory and general cognitive abilities.
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