CENPI Human Gene Knockout Kit (CRISPR)
CENPI - human gene knockout kit via CRISPRchange donor?
KN222551G1, CENPI gRNA vector 1 in pCas-Guide vector,
KN222551G2, CENPI gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001318521, NM_001318523, NM_006733, XM_005262111, XM_011530894, XM_011530895, XM_011530897, XM_011530899, XM_017029383|
|Synonyms||CENP-I; FSHPRH1; LRPR1|
|Summary||This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016].|
|Gene Expression Resources|
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