ERBB4 Human Gene Knockout Kit (CRISPR)
ERBB4 - human gene knockout kit via CRISPRchange donor?
KN220449G1, ERBB4 gRNA vector 1 in pCas-Guide vector,
KN220449G2, ERBB4 gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001042599, NM_005235, XM_005246376, XM_005246377, XM_006712364, XM_017003577, XM_017003578, XM_017003579, XM_017003580, XM_017003581, XM_017003582, XM_172034|
|Synonyms||ALS19; HER4; p180erbB4|
|Summary||This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]|
|Gene Expression Resources|
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