LPO Human Gene Knockout Kit (CRISPR)
LPO - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN218093G1, LPO gRNA vector 1 in pCas-Guide vector
KN218093G2, LPO gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001160102, NM_006151, NR_027647, XM_011524808, XM_011524810, XM_042207|
|Synonyms||MGC129990; MGC129991; SPO; salivary peroxidase; lactoperoxidase|
|Summary||This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].|
|Gene Expression Resources|